Indianapolis Colts vs Jacksonville Jaguars: Odds, Spread, and Total
The Indianapolis Colts will look to end their two-game losing streak and pass the Jacksonville Jaguars for first in the division. These teams battle on Sunday afternoon at 1 p.m. EST.
Montaric Brown #30 and Greg Newsome II #6 of the Jacksonville Jaguars celebrate a turnover on downs by the Tennessee Titans during the second half at Nissan Stadium on November 30, 2025 in Nashville, Tennessee.
Photo by Jeff Dean/Getty ImagesThe Indianapolis Colts will look to end their two-game losing streak and pass the Jacksonville Jaguars for first in the division. These teams battle on Sunday afternoon at 1 p.m. EST.
The Colts are 8-4 and second in the AFC South Division. They just lost to the Houston Texans at home, 20-16. From start to finish, it was a back and forth game, mixed with field goals and touchdowns, and Indy just fell short in the fourth quarter. The Colts lost in total yards 364-281 and 256-195 in passing yards. They lost in time of possession but did win the turnover battle 1-0. The red zone offense was 2-for-4 and the red zone defense was 3-for-5 on stops. Running back Jonathan Taylor led the way on offense with 21 carries for 85 yards.
The Jaguars are 8-4 and first in the AFC South Division. They just beat the Tennessee Titans on the road 25-3. The Titans scored first with a field goal, but from there, the Jaguars slowly built a solid lead. Both teams struggled on third downs and the Jacksonville third down defense was 10-for-12 on stops. The Jags won in total yards 272-188 and in passing yards 202-121. They had the slight edge in time of possession and won the turnover battle 2-0. The red zone offense was 2-for-2 and the red zone defense was 1-for-1 on stops. Quarterback Trevor Lawrence led the way on offense, going 16 of 27 for 229 yards and two touchdowns.
Spread
- Colts -2.5 (+100)
- Jaguars +2.5 (-113)
Money line
- Colts -122
- Jaguars +117
Total
- OVER 47.5 (-104)
- UNDER 47.5 (-113)
Note: The above data was collected on Dec. 5, 2025, and may have changed since writing.
Colts vs Jaguars Betting Trends
- Indianapolis is 9-4 SU in its last 13 games.
- Indianapolis is 2-9 ATS in its last 11 games against Jacksonville.
- Indianapolis is 2-5 SU in its last seven games against Jacksonville.
- Jacksonville is 4-1 SU in its last five games.
- The total has gone OVER in five of Jacksonville's last five games against Indianapolis.
- The total has gone UNDER in six of Jacksonville's last seven games at home.
Colts vs Jaguars Injury Reports
Indianapolis Colts
- Tyquan Lewis, DE - Questionable
- Sauce Gardner, CB - Doubtful
- Jaylon Carlies, LB - Injured reserve
- Ashton Dulin, WR - Injured reserve
- DeForest Buckner, DT - Injured reserve
- Anthony Richardson Sr., QB - Injured reserve
- Mike Hilton, CB - Out
- Spencer Shrader, PK - Injured reserve
- Daniel Scott, S - Injured reserve
- Hunter Wohler, S - Injured reserve
- Jacob Phillips, LB - Injured reserve
- Blake Freeland, OT - Injured reserve
- D.j. Montgomery, WR - Injured reserve
- Justin Walley, CB - Injured reserve
- Salvon Ahmed, RB - Injured reserve
- Jack Wilson, OT - Injured reserve
Jacksonville Jaguars
- Patrick Mekari, G - Questionable
- Parker Washington, WR - Questionable
- Chuma Edoga, G - Questionable
- Walker Little, OT - Questionable
- Travon Walker, DE - Questionable
- Andrew Wingard, S - Questionable
- Logan Cooke, P - Questionable
- Arik Armstead, DT - Questionable
- Ross Matiscik, LS - Questionable
- Eric Murray, S - Injured reserve
- Travis Hunter, WR - Injured reserve
- Jalen McLeod, LB - Injured reserve
- Caleb Ransaw, CB - Injured reserve
- Joshua Cephus, WR - Injured reserve
- Cooper Hodges, OT - Out
Colts vs Jaguars Predictions and Picks
Indianapolis is currently ranked seventh in passing yards, sixth in rushing yards, first in points scored, and tied for ninth in points against. The Colts have dropped three of their last four games and are trying to regain first place. Indy has not won a road game in Jacksonville since 2014 and has lost 10 in a row there. Taylor is the NFL's leading rusher and is going up against the best rushing defense in the league. Quarterback Daniel Jones is playing through an injury and has faced a decent amount of pressure in the last few losses.
Jacksonville is ranked 21st in passing yards, 11th in rushing yards, 11th in points scored, and 12th in points allowed. The Jags have won four of their last five games and the winner of this game will hold the head-to-head tie-breaker for the division race. The Jacksonville defensive line will look to pressure Jones as much as they can and try to bottle up Taylor early on. The offense needs to match the Colts' red zone efficiency and also take care of the football. The Jaguars' defense has been trending up during this little winning streak, and they will look for some big stops or takeaways.
Best Bet: Colts Spread
The Colts have been playing well for most of the season and this is their first losing streak. They have the best running back in the game this season and this could be a statement game for them to get back on track. The Jaguars have been playing good football, but the last two games were against below-average teams.
